N-Acetyl-L-Carnosine — Bulk Raw Material

N-Acetyl-L-Carnosine — Anti-Glycation Dipeptide for Eye Care & Anti-Aging

N-Acetyl-L-Carnosine (NAC) is a naturally occurring dipeptide derivative of carnosine (β-alanyl-L-histidine), supplied as high-purity bulk powder for ophthalmic manufacturers, nutraceutical brands, and cosmetic formulators. Unlike L-carnosine — which is rapidly hydrolyzed by serum carnosinase before reaching target tissues — N-acetyl-L-carnosine is resistant to enzymatic degradation, enabling it to reach the eye lens and other tissues intact as a sustained-release prodrug of L-carnosine.

Why NAC Outperforms L-Carnosine

• Enzymatic resistance — the acetyl group protects NAC from rapid hydrolysis by serum carnosinase, delivering intact carnosine to target tissues including the aqueous humor and lens
• Anti-glycation activity — inhibits advanced glycation end-products (AGEs) and cross-linking of lens crystallin proteins; the primary mechanism behind cataract prevention
• Lipid peroxidation inhibition — scavenges lipid peroxyl radicals and protects cell membranes from oxidative damage
• Metal chelation — chelates transition metals (Cu²⁺, Fe²⁺) that catalyze oxidative reactions in lens tissue
• pH buffering — maintains physiological pH in biological systems

Technical Profile for Formulators

• Chemical name: N-Acetyl-L-carnosine (N-acetyl-β-alanyl-L-histidine)
• CAS: 56353-15-2
• Molecular formula: C₁₁H₁₆N₄O₄
• Molecular weight: 268.27
• Appearance: White crystalline powder
• Purity: ≥ 98.0% (HPLC)
• Particle size: 80–100 mesh
• Solubility: Water-soluble
• Storage: 2–8°C, protected from moisture and light

Applications by Sector

Ophthalmic Manufacturers:

• Anti-cataract eye drops (1% NAC ophthalmic solution)
• Dry eye and ocular surface disorder formulations
• Presbyopia eye drop research formulations
• Veterinary ophthalmic drops (canine cataract management)

Nutraceutical & Supplement Brands:

• Anti-glycation and longevity supplements
• Skin anti-aging capsules (oral carnosine bioavailability enhancer)
• Combination formulations with lipoic acid or other antioxidants

Cosmetic Formulators:

• Anti-glycation serums and creams
• Periocular anti-aging products
• Advanced glycation end-product (AGE) defense formulations

Quality Assurance

HPLC purity verification per batch. COA, MSDS, and heavy metals report provided with each shipment. Full documentation traceability for regulatory submission support.