Liposomal Fisetin 50% 70%

Fisetin — Liposomal Bulk Raw Material for Anti-Aging & Beauty

Liposomal Fisetin delivers a flavonoid polyphenol that has gained widespread attention for its senolytic properties—the ability to selectively clear senescent (zombie) cells that accumulate in aging skin and secrete collagen-degrading enzymes. Extracted from Rhus succedanea and encapsulated at 50% and 70% liposomal concentrations, fisetin inhibits MMP-9 gelatinase, suppresses pro-inflammatory SASP factors, and activates the Nrf2 antioxidant pathway. Its unique senolytic mechanism distinguishes it from all other flavonoid anti-aging ingredients.

Available Purity Grades

• Fisetin 50% 70% (HPLC) — Liposomal powder with phosphatidylcholine encapsulation for enhanced bioavailability.

Why Choose Our Liposomal Fisetin?

• Senolytic Cell Clearance: Induces apoptosis preferentially in senescent fibroblasts through inhibition of anti-apoptotic PI3K/Akt and BCL-2 pathways, clearing zombie cells that secrete collagen-degrading SASP factors.
• MMP-9 Gelatinase Inhibition: Directly inhibits gelatinase MMP-9, the primary enzyme responsible for degrading denatured collagen (gelatin) in photoaged and chronically inflamed skin.
• SASP Suppression: Downregulates the senescence-associated secretory phenotype, reducing IL-6, IL-8, and MMP-1 secretion from residual senescent cells that escape clearance.
• Nrf2 Pathway Activation: Potently activates the Keap1-Nrf2-ARE antioxidant defense system, upregulating heme oxygenase-1 and NAD(P)H quinone oxidoreductase 1 for robust cytoprotection.
• Anti-Inflammatory Efficacy: Suppresses COX-2 and 5-LOX enzyme activity, blocking both prostaglandin and leukotriene inflammatory pathways that drive chronic dermal inflammation and collagen loss.
• MAO-B Inhibition: Inhibits monoamine oxidase-B in dermal nerve endings, reducing oxidative stress at the neurocutaneous junction and potentially modulating local neurogenic inflammation.

Target Applications

• Senolytic Skincare Pioneers: Innovative brands developing the first generation of senolytic anti-aging products that clear senescent cells and restore youthful fibroblast populations in the dermis.
• Longevity Cosmeceutical Companies: Brands positioning products at the intersection of geroscience and skincare, leveraging fisetin's published senolytic research for science-forward marketing claims.

Quality & Compliance

• GMP-certified production facilities
• Liposomal encapsulation verified by DLS particle size analysis
• COA provided with every shipment
• Heavy metals compliant (Pb ≤ 2 ppm, As ≤ 1 ppm)
• Custom packaging and private labeling available
• Stable shelf life: 24 months (cool, dry storage, protected from light)

Bulk Supply & OEM Service

We supply liposomal Fisetin in bulk quantities (sample to 25 kg drums) for B2B buyers, contract manufacturers, and private-label brands. Contact our technical team for quotes, sample requests, or formulation consultation.